Orlistat (Xenical or generic) is MHRA-approved for weight loss in adults with a BMI ≥30 or ≥28 with weight-related conditions, alongside a reduced-calorie, low-fat diet. It reduces fat absorption by about 30%, leading to 5–10% weight loss over 6–12 months in trials. It’s safe when prescribed or purchased over-the-counter (as Alli, 60 mg) and used as directed.

Orlistat works by blocking fat absorption in the gut, unlike Wegovy (semaglutide) or Mounjaro (tirzepatide), which suppress appetite via GLP-1 or dual GLP-1/GIP action. Orlistat achieves 5–10% weight loss, less than Wegovy (15%) or Mounjaro (20–22.5%). It has fewer systemic side effects but more gastrointestinal issues. Orlistat is cheaper making it more accessible. Our clinician can advise based on your goals.

Can I trust the manufacturers of Orlistat (Xenical and generic) in the UK?
Xenical is made by Roche, and generics are produced by MHRA-approved manufacturers like Teva or Accord. Both are regulated by the MHRA, ensuring quality and safety. Roche has a strong reputation, while generic manufacturers meet strict UK standards. Some users prefer branded Xenical for perceived consistency, but generics are equally effective. Our clinicians are here to help for confidence in either option.

Orlistat is suitable for UK adults with a BMI ≥30 or ≥28 with conditions like hypertension, combined with a low-fat diet. It’s less effective than injectables like Wegovy but has a well-established safety profile. Gastrointestinal side effects may deter some users. Our clinicians can assess suitability for your lifestyle and weight loss needs.

Buying Orlistat from unregulated online sources risks counterfeit or substandard products. Reputable UK online pharmacies, like Boots Online Doctor or LloydsPharmacy, require a consultation for Xenical (120 mg) or sell Alli (60 mg) over-the-counter with guidance. Verify General Pharmaceutical Council (GPhC) and MHRA registration to avoid scams or unsafe medications.

Common side effects (oily stools, flatulence, urgent bowel movements) are tied to dietary fat intake and can be socially inconvenient or disruptive, especially initially. These are manageable with a low-fat diet. Rare serious risks, like liver issues, require NHS attention. Discuss with our clinicians to gauge lifestyle impacts and mitigation strategies.

Orlistat delivers 5–10% weight loss over 6–12 months with a low-fat diet, compared to 2–5% for diet and exercise alone in trials. Non-medication methods, like Slimming World or NHS programmes, yield similar or slightly lower results but avoid side effects. Orlistat enhances weight loss but requires dietary discipline for best outcomes.

UK reviews report 4–10 kg weight loss with Orlistat, but some highlight side effects like oily stools. Reviews may be biased, and social media posts can exaggerate benefits or issues. Verify claims with clinical trial data and consult our clinicians to avoid misinformation. On our site we only use data from highly regarded trials and authentic reviews to avoid misinformation when choosing Xenical or generic.

Orlistat may reduce absorption of fat-soluble vitamins (A, D, E, K) or medications like oral contraceptives. It’s unsuitable for those with malabsorption syndromes or cholestasis. Our clinicians will review your medical history and prescriptions to ensure safety, recommending vitamin supplements if needed.

Xenical (Roche) and generic Orlistat (e.g., Teva) contain the same active ingredient (120 mg) and are equally effective, with generics often cheaper. Both require ongoing use with a low-fat diet to maintain 5–10% weight loss; stopping without lifestyle changes risks weight regain. Costs vary (£30–£60/month for 120 mg via UK pharmacies). Consider dietary commitment and costs (Xenical vs. generic).  Our clinicians can help plan for suitability and sustainability before starting.